INS and Insulin resistance: Wang et al. [95] evaluated the effects of intraperitoneally administered OA (20 mg/kg/day for two weeks) on hepatic insulin resistance in Lepdb/db obese diabetic mice and observed a decrease in lipid accumulation, cellular and mitochondrial ROS production as well as in the levels of IL-1β, IL-6 and TNFα, whereas enhanced insulin signaling and inhibited gluconeogenesis.