On the other hand, in vivo experiments using diet supplementation with proanthocyanidins from grape seeds on Miapaca-2 pancreatic tumor xenografts grown subcutaneously in athymic nude mice resulted in reduction of tumor growth, increased expression of Bax, reduction of anti-apoptotic proteins, and activation of caspase-3-positive cells [132]. The gene discussed is CASP3; the disease is pancreatic neoplasm.