After these initial findings, many more inflammatory mediators were shown to be linked to obesity, for example, the anti-inflammatory peptide hormone adiponectin [34], acute-phase proteins such as CRP, and pro-inflammatory cytokines such as IL-6 [35], among more than fifty inflammatory molecules related to adiposity [36,37]. The gene discussed is CRP; the disease is obesity due to melanocortin 4 receptor deficiency.