The seemingly reduced activity of MTR in PD subjects with dementia is not connected to folates, since folate levels are unchanged for DOPA− cases, and could be a result of deficiency in other related B vitamins (B2, B6, B12) or enzymatic inefficiency (besides MTR, other relevant enzymes are methionine synthase reductase, methylenetetrahydrofolate reductase, methylenetetrahydrofolate dehydrogenase, and serine hydroxymethyltransferase). The gene discussed is MTHFR; the disease is dementia.