The seemingly reduced activity of MTR in PD subjects with dementia is not connected to folates, since folate levels are unchanged for DOPA− cases, and could be a result of deficiency in other related B vitamins (B2, B6, B12) or enzymatic inefficiency (besides MTR, other relevant enzymes are methionine synthase reductase, methylenetetrahydrofolate reductase, methylenetetrahydrofolate dehydrogenase, and serine hydroxymethyltransferase). This evidence concerns the gene MTHFR and Parkinson disease.