ICAM1 and inflammatory bowel disease: This action has been more thoroughly investigated in inflammatory bowel diseases, where mastic has been found to decrease the cytokines tumor necrosis factor-a, malonaldehyde, intercellular adhesion molecule-1 (ICAM-1) and interleukin -6, -8 and -10, both in preclinical and clinical studies; thus, efficiently inhibiting intestinal damage [26,27].