URAT1, also known as SLC22A12, is a physiologically important renal urate re-absorber; its dysfunction causes renal hypouricemia type 1 [6,7], a genetic disorder characterized by impaired renal urate reabsorption, associated with extremely low serum urate levels (serum urate ≤ 2 mg/dL [8,9]; normal range: 3.0 to 7.0 mg/dL). The gene discussed is SLC22A12; the disease is hereditary disease.