NFE2L2 and metabolic dysfunction-associated steatotic liver disease: Upregulation of Nrf2 induced by oxidative stress is positively regulated for cell defense; in this instance, upregulation of Nrf2 induced by baicalin was masked, which suggested the mechanism of baicalin-mediated antioxidation was not mainly dependent on the Nrf2 pathway in the 3D model of NAFLD.