TYRP1 and Anterior synechiae of the anterior chamber: For instance, the D2 mouse presents a late-onset, chronic pigmentary glaucoma due to the high IOP that progresses with age, resulting from tyrosinase-related protein 1 (Tyrp1) mutation and a premature stop codon in glycoprotein non-metastatic melanoma protein B (Gpnmb), which collectively lead to anterior segment anomalies, iris atrophy, peripheral anterior synechiae and pigment dispersion [64,65].