AKT1 and lip and oral cavity carcinoma: Additionally, lycopene appears to inhibit the epithelial–mesenchymal transition in murine CAL-27 oral cancer xenograft model cells, as demonstrated by changes in cadherin activity [75,139], and to slow the in vitro motility of CAL-27 and SCC-9 oral cancer cells via regulation of the PI3K/AKT/mTOR signalling [75,140].