For instance, in a pilot randomized clinical trial, Moody and collaborators [36] identified high circulating lycopene levels in one group of HNC survivors with various stages of cancer of the oral cavity, pharynx, or larynx after posttreatment ≥6 months; these patients demonstrated substantial differential epigenetic methylation status of transcriptional and translational regulators, as well as of targeted genes of receptor signalling in the immunocompetent T cell (i.e., hypermethylation of CD40 ligand and Tec protein tyrosine kinase and hypomethylation of CD8A). Here, CD8A is linked to cancer.