NLRP3 and lung disorder: As an example, the major bioactive component of Trametes orientalis, used for the treatment of pulmonary disease, is a polysaccharide composed of galactose, glucose, mannose, and arabinose with molar ratios of 5.79:5.77:3.45:1.20 (average MW 63000), which proved to inhibit the activation of NLRP3 inflammasome and the release of pro-inflammatory cytokines, including TNF-α, IL-1β, and IL-6, by the detection of expression levels of proteins in lung tissue involved in the NLRP3 inflammatory pathway [123].