These pathologies are characterized by a variable increase in serum biomarkers level of inflammation, especially TNF-α, IL-1β, IL-6, PCR, fibrinogen, intercellular (ICAM1), and vascular (VCAM1) adhesion molecules, etc. These biomarkers were also shown to be significantly related to the risk of T2D, cardiovascular disease and cancers in healthy subjects [23]. The gene discussed is IL1B; the disease is cardiovascular disorder.