All data reported the anti-inflammatory properties of EPA and DHA resulting in a downregulation of NLRP3 gene expression and in a decreased secretion of pro-inflammatory cytokines (IL-1β and IL-18) in obesity models [102,103], in DSS-induced colitis in mice [104], in LPS-induced Kupffer cells [105], and in both prefrontal cortex and hippocampus of rats [106]. This evidence concerns the gene IL1B and obesity due to melanocortin 4 receptor deficiency.