In addition, under the VLFC condition, CRY1 rs3741892 had a significantly greater obesity risk than the reference regardless of genotype (GG genotype, OR: 1.60, 95% CI: 1.22–2.10, p = 0.0007; GA/GG genotype, OR: 1.76, 95% CI: 1.30–2.38, p = 0.0002). This evidence concerns the gene CRY1 and obesity due to melanocortin 4 receptor deficiency.