In the male VLFC group, the minor allele carriers of CLOCK rs9312661, CRY2 rs7951225, and the GG genotype of CRY1 rs11113192 showed increased risks of obesity; however, significances were diminished after the Bonferroni correction (Table 4). The gene discussed is CRY1; the disease is obesity due to melanocortin 4 receptor deficiency.