ERBB2 and obesity due to melanocortin 4 receptor deficiency: Women with obesity have a higher risk of developing triple-negative breast cancer (TNBC) anyway [42], a subtype of BC which, for growth and progression, is independent of estrogen, progesterone, and human epidermal growth factor 2 protein (HER2), and therefore is characterized by poorer prognosis with an increased risk of metastatic disease and lower survival rates.