TCF7L2 and type 2 diabetes mellitus: Interestingly, irrespectively of the meal consumed, the postprandial acylcarnitine AUC in the high-risk group was reduced, suggesting a compensatory increase in fatty acid oxidation that could prevent lipid accumulation, as already seen in nondiabetic TCF7L2 HR-genotype carriers (TCF7L2, responsible for the T2D predisposition) [79].