N-Acylethanolamines (NAEs) are fatty acid amides that share synthesis and degradation enzymes with endocannabinoid molecules and, even though they do not act on the cannabinoid receptors, they are active on TRPV1, PPARs and GPR119 and GPR55, which have been associated with the same effects as CB2 (improvement of glucose intolerance, perturbed intestinal permeability, insulin resistance and obesity) and are part of the endocannabidiome receptors [125,126]. Here, CNR2 is linked to obesity due to melanocortin 4 receptor deficiency.