CNR1 and obesity due to melanocortin 4 receptor deficiency: Quercetin has demonstrated to have a high affinity towards CB1, comparable to the affinity Rimonabant shows towards the same receptor (−6.56 Kcal/mol with four hydrogen bonds), leading the authors of the study to believe that this specific compound could be a promising and ideal lead molecule for novel obesity treatment, even though only a few studies have explored this relationship at the moment.