Oral or intra-peritoneal delivery of H120 or H182 as a single agent inhibited human TNBC xenografts growth, and H278 (H182 hydrochloric acid salt) combined with radiation therapy completely blocked tumor growth and prolonged survival in mouse TNBC syngeneic models that harboraberrantly-active Stat3. The gene discussed is STAT3; the disease is neoplasm.