All these three UniProt features have been found to be the signature of IDRs that are intolerant to mutations in our study (Fig 5A), and indeed, germline variants causing deletion of Emerin or introducing small changes in the IDR of Emerin (i.e. by missense and inframe variations, Fig 6B and S5 Table) have been found to be responsible for X-linked Emery-Dreifuss muscular dystrophy [71,72]. The gene discussed is EMD; the disease is Emery-Dreifuss muscular dystrophy.