p53, an essential tumor suppressor, prevents tumor progression; a recent study has indicated that inhibition of p53 expression induced by LINC00467 upregulation promotes proliferation and invasion abilities of glioma cells.22 In addition, activated p53 confers an inhibitory effect on glioma tumor growth following a xenograft tumor model construction.23 These findings suggested that p53 may be a potential target for diagnostics and therapeutics in glioma. This evidence concerns the gene TP53 and central nervous system cancer.