TP53 and central nervous system cancer: It was found that cell apoptosis was suppressed by siRNA-p53 yet promoted by siRNA-PVT1, while co-transfection of siRNA-p53 and siRNA-PVT1 neutralized the function of siRNA-p53 (Figure 3g), highly suggestive of the promoting action of p53 on glioma cell apoptosis by targeting lncRNA PVT1.