We previously induced nephron specific Ift88 gene KO (Ift88 KO) in mice at 2 months of age; male mice developed PKD 9 months post Ift88 KO (at 11 months of age), while female Ift88 KO mouse kidneys had normal or rare renal cysts at this age (Hu et al., 2021). Here, IFT88 is linked to cystic kidney disease.