The current study made the following key observations: (1) Relatively hypotensive pre‐cystic Ift88 KO male mice have reduced renal NKCC2 expression; and (2) hypertensive Ift88 KO males with polycystic kidneys have increased total and phosphorylated NHE3 expression associated with decreased NKCC2, NCC, and ENaC protein levels. The gene discussed is SLC9A3; the disease is polycystic kidney disease.