GPD2 and lactic acidosis: Interestingly, Schulman and colleagues linked inhibition of hepatic gluconeogenesis to lactic acidosis by showing a Metformin‐mediated modulation of cytosolic redox state through inhibition of mGPDH; the consequences of this could include prevention of glycerol entry into gluconeogenic flux, disruption of the glycerophosphate shuttle, and accumulation of cytosolic NADH which does not favor lactate conversion to pyruvate via lactate dehydrogenase (Madiraju et al., 2014; Petersen et al., 2017).