SPP1 and cancer: Genes upregulated by >1.5‐fold in cancer tissues rather than in normal intestinal mucosae include Wnt signaling‐related genes such as Fzd1 (fold change [FC], 5.6), Myc (FC, 2.6), Ccnd1 (FC, 1.6), Mmp2 (FC, 10.4), Mmp7 (FC, 16.0), Mmp8 (FC, 12.9), Mmp12 (FC, 52.2), and Spp1 (FC, 149.3).