Treatment with various Wnt/β‐catenin inhibitors, such as CCT031374 and β‐catenin/Tcf inhibitors II and V, suppressed in vitro proliferation and β‐catenin reporter activity of Villin‐Cre; Smad4F/F; Trp53F/F cells primary cultured from autochthonous intestinal cancers (primary #1 cells) (Figure S3A). The gene discussed is HNF4A; the disease is intestinal cancer.