Another study revealed that p300 interacting with signal transducer and activator of transcription 1 could increase the H3K27ac level in the enhancers of TNFAIP2 and LCP2, which may contribute to the development of inflammatory bowel disease, and the p300 inhibitor significantly inhibited the disease in an acute colitis mice model.15 This evidence concerns the gene EP300 and inflammatory bowel disease.