In addition, the modification of histone H3 on the CRE site within the IL17A promoter was involved with H3K18 hyperacetylation and H3K27 hypomethylation in SLE T cells, which resulted from the recruitment of HDAC1 and DNA methyltransferase3a to the CRE site.10 This evidence concerns the gene HDAC1 and systemic lupus erythematosus.