TMEM200B and cancer: Previous studies have noted a strong correlation between bTMB and tTMB in patients with cancer; however, these studies failed to evaluate overall concordance.20,21 We demonstrate herein that despite a strong correlation, bTMB typically reports higher than tTMB ultimately resulting in conflicting “high” versus “low” statuses in over one-third of patient cases wherein both blood- and tissue-NGS are performed (Fig. 1).