This study detected JKAP, IFN‐γ, IL‐4, IL‐17, TNF‐α, ICAM‐1, and VCAM‐1 in 122 AIS patients and JKAP in 50 controls to evaluate the association of JKAP with disease severity, Th1, 2, 17 secreted cytokines, adhesion molecules, and prognosis of AIS patients. The gene discussed is IL4; the disease is androgen insensitivity syndrome.