The analysis demonstrated that in comparison with normal brain tissues, 20 pyroptosis-related genes were upregulated in the tumor (e.g. CASP1 and CASP3), and 11 pyroptosis-related genes were significantly downregulated in the tumor (e.g. GSDMB and NLRP1) (Fig. 1d). The gene discussed is GSDMB; the disease is neoplasm.