It was found that the NLRP2, NLRP3, NLRP7, PLCG1, SCAF11, NLRP1, NOD1, CASP1, and NOD2 exhibited relatively high mutation frequency (1%), while CASP3, GSDME, IL1B, PJVK, TIRAP did not show any mutations in glioma samples (Fig. S1b). The gene discussed is CASP1; the disease is central nervous system cancer.