On the one hand, activation of TRPML1 has been reported to disrupt the autophagic process and induce cell cycle arrest (Qi et al., 2021), while on the other hand, inhibition of TRPML1 function has also been reported to impair autophagy induction and inhibit cancer cell invasion and migration (Rühl et al., 2021). Here, MCOLN1 is linked to cancer.