In contrast, Yoda1 impedes cell migration in transformed fibroblasts (Chubinskiy-Nadezhdin et al., 2019), and here, we found that contact compression and Yoda1-activation of Piezo1 reduced both spontaneous and thrombin-induced blebbing in MDA-MB-231 breast cancer cells, which is likely to limit their capacity to engage in amoeboid migration. This evidence concerns the gene PIEZO1 and breast cancer.