In SCD, there is reduced peripheral blood expression of SOD2 and this decrease in SOD2 is associated with increased hemolysis, inflammation, iron overload, oxidative stress, and SCD cardiomyopathy.26 While reduction of peripheral blood SOD2 has been reported, the study was limited due to a small sample size and select patient population. Here, SOD2 is linked to Schnyder corneal dystrophy.