XAF1 and sarcoma: XAF1 induction of P-AMPK was also detected in multiple nonglioma cells, including IMR90 (fibroblast), T47D (breast), HCT116 (colon), and U2OS (sarcoma) and XAF1 depletion disrupted TMZ cytotoxicity in XAF1 expression subline of PC3 (prostate) (Supplementary Figure S3F–H).