LDHA and brain neoplasm: Knockdown induced by shRNAs against CARM1 mRNA in glioblastoma (LN229) and neuroblastoma [BE(2)-C] cell lines inhibited the proliferation in both cell types, demonstrating the functional impact of this gene in both brain tumors.53 These authors also found that CARM1 downregulation was associated with decreasing mRNA or protein levels of LDHA, GLUT1, and ASCT2 genes.