Embryonic stem cell gene expression signatures for OCT4A, SOX2, and CARM1 genes in GBM samples were found, and given their well-documented influences on an array of downstream targets, we suggest that the expression of these factors can be involved in the embryonic-like features present in these tumors, as previously documented by other authors.46 We also suggest that the expression of OCT4A, in two nonneoplasic samples, could represent a possible stem cell niche with at least one embryonic feature in adult brain tissue. The gene discussed is SOX2; the disease is glioblastoma.