TP53 and cancer: Increased CARM1 expression and/or activity have previously been reported in many different cancer types, including prostate, breast, colorectal, lung, and liver cancer.48–50 In solid tumors, CARM1 acts as a cofactor for the transcription factor NF-κB, p53, steroid hormone receptors and, it is functionally related to cancer cell proliferation, metastasis, and poor survival outcomes.51