SOX2 plays a critical role in the carcinogenesis and maintenance of GBM stem cells, associated with resistance to chemotherapy and radiotherapy.45 The same authors reported that increased SOX2 expression enhanced stem cell potency in GBM cell lines, while downregulation of this gene was associated with abrogated ability of tumor initiation and drug resistance of CD133+ GBM cells.45 Here, SOX2 is linked to glioblastoma.