BACE1 and coronary atherosclerosis: For example, dysregulation of the BACE1/BACE1-AS/β-amyloid axis was linked to the pathogenesis of heart failure (49); Aβ is contributory in the development of coronary atherosclerosis and is implicated in the pathophysiology of ischemic heart disease and myocardial ischemia/reperfusion injury (30).