RYR2 and arrhythmogenic right ventricular cardiomyopathy: To date, some genes have been associated with the ARVC phenotype including desmosomal genes (PKP2, DSG2, DSP, DSC2, and JUP) and non-desmosomal genes (LMNA, CTNNA3, CDH2, DES, TTN, PLN, RYR2, SNC5A, and TP63) (1).