The genetic alteration of FUBP1 in different cancers was investigated according to the clinical datasets in TCGA, the highest alteration frequency for FUBP1 appeared in patients with low-grade glioma, showing an alteration frequency of nearly 10%, while no alteration in FUBP1 was observed in patients with uveal melanoma, uterine carcinosarcoma, thymoma, testicular germ cell tumors, pancreatic adenocarcinoma, mesothelioma, diffuse large B-cell lymphoma, or cholangiocarcinoma. The gene discussed is FUBP1; the disease is cholangiocarcinoma.