High expression of IQGAP3 was mainly involved in “cell cycle,” “ECM-receptor interaction,” and “miRNA in cancer” in BRCA (Figure 9A); “spliceosome” and “human T cell virus” in COAD (Figure 9B); “cell cycle” and “lysosomes” in KIRP (Figure 9C); “PI3K-AKT signaling pathway” and “rap1 signaling pathway” in LGG (Figure 9D); “cell cycle” and “RNA transport” in LIHC (Figure 9E) “cell cycle,” “spliceosome,” and “RNA transport” in LUAD (Figure 9F); “cell adhesion” and “cell cycle” in LUSC (Figure 9G); “Nod-like receptor signaling pathway” and “tight junctions” in PAAD (Figure 9H). This evidence concerns the gene AKT1 and cancer.