Recent studies suggest that disturbances/fluctuations in BDNF synthesis and function are associated with devastating CVDs such as heart failure, arrhythmia, and MI, indicating its importance to the cardiac system (Kadowaki et al., 2016; Pius-Sadowska and Machaliński, 2017; Panhwar et al., 2019). This evidence concerns the gene BDNF and heart failure.