IBD-related genes Caspase recruitment domain family member 9 (CARD9), Nucleotide binding oligomerization domain containing 2 (NOD2), Autophagy related 16 like 1(ATG16L), Immunity related GTPase M (IRGM), and Fucosyltransferase 2 (FUT2) are significantly associated with the low abundance in the genus Roseburia (Imhann et al., 2018). The gene discussed is NOD2; the disease is inflammatory bowel disease.