KIT and neoplasm: On the other hand, NCCS-GIST-02 switched from avapritinib to imatinib and subsequently ripretinib as a result of lack of response in terms of tumor reduction in the first 8 weeks of monitoring; the KIT variants from exon 11 c.1727T>C and exon 17 c.2466T>A became undetectable from week 10 to week 16 (Figure 3C), correlating with positive response to ripretinib treatment.