PIK3CA and non-small cell lung carcinoma: In addition, the mutation frequencies of the 10 most common mutated genes (e.g., EGFR, TP53, PIK3CA, RB1, CD3EAP, CTNNB1, ERBB2, APC, ERBB2, FGFR2) in LUAD were different from that in LUSC, further indicating that the differences in genetic mutations exist in NSCLC subtypes (63–66).