In addition, the mutation frequencies of the 10 most common mutated genes (e.g., EGFR, TP53, PIK3CA, RB1, CD3EAP, CTNNB1, ERBB2, APC, ERBB2, FGFR2) in LUAD were different from that in LUSC, further indicating that the differences in genetic mutations exist in NSCLC subtypes (63–66). This evidence concerns the gene RB1 and non-small cell lung carcinoma.