RYR1 and atrial fibrillation: The key gene markers obtained by the two algorithms overlapped, and six key genes, consisting of three downregulated genes (CHRNA5, LOC150051, and PP12719) and three upregulated genes (DHRS9, LOC101928304, and RYR1), were screened as novel gene markers for AF (Figures 4(a)–4(d)).