Notably, 40% of the COVID-19 patients were negative for both KIR3DL1+HLA-Bw4+ and KIR3DL2+HLA-A3/11+ combinations compared to 24.6% of the general population (OR = 2.04, p = 0.001, CI = 1.33–3.14). This evidence concerns the gene KIR3DL1 and COVID-19.