Although Asian populations have a lower APOE ε4 frequency (6.9%) (Hu et al., 2011) than Europeans (10–15% in the south to 40–50% in the north) (Ewbank, 2004), the prevalence of cognitive impairment in the Chinese population (Hilal et al., 2013) is still in a similar range to the prevalence reported in Caucasians (Alexander et al., 2015). Here, APOE is linked to Cognitive impairment.