Meanwhile, we examined the association of cholesterol with MCI-AD progression in subgroups stratified by APOE ε4 status and found that LDL-C was also inversely associated with incident AD in APOE ε4 carriers in Cox regression (HR = 0.43, 95%CI = 0.19–0.97, p = .043; Supplementary Figure S1, model 2). The gene discussed is APOE; the disease is Alzheimer disease.