The Framingham Heart Study (n = 3040) examined the effects of mid-life lipid levels on AD based on AD-risk genetic variants and found that the effect of triglycerides on AD varies according to the sortilin-related receptor 1 (SORL1) SNP rs11218343, but no interaction occurred between AD-risk SNPs and the LDL-C level on the risk of AD. Here, SORL1 is linked to Alzheimer disease.