NECTIN2 and Alzheimer disease: Our results suggest that genetic factors might influence the relationship between LDL-C and risk of incident AD, providing a possible explanation for inconsistent LDL-C-cognition association from previous population-based study (Li et al., 2005; Reitz et al., 2005; Reitz et al., 2010; Benn et al., 2017; Schilling et al., 2017; Zhou et al., 2018) and suggesting that among individuals with PVRL2 rs6859 AG/AA, aggressively lowering LDL-C might not be beneficial to prevent cognition impairment.