As shown in Figure 3, among MCI participants with PVRL2 rs6859 AG/AA genotype, those maintaining medium/high LDL-C (2.86-3.67 mmol/L/> 3.67 mmol/L) had a significantly decreased cumulative risk of AD compared with those with low LDL-C (<2.86 mmol/L) (P for trend = .016, Pmedium vs. low= .002, Phigh vs. low= .015; Figure 3A). Here, NECTIN2 is linked to Alzheimer disease.