In recent years, a review of the AD related Genome-wide association study (GWAS) indicated that several AD risk SNP-related genes may cluster in cholesterol and lipid metabolism pathways (Van Cauwenberghe et al., 2016), such as APOE, clusterin (CLU), ATP-binding cassette transporter A7 (ABCA7), and poliovirus receptor–related 2 (PVRL2) (Ma et al., 2018; Mahley and Rall, 2000; Van Cauwenberghe et al., 2016). This evidence concerns the gene APOE and Alzheimer disease.