Therefore, we conducted an MR analysis to investigate the causal effect of NT-proBNP on ischemic stroke and its subtypes (cardioembolism stroke, small-vessel occlusion stroke, and large-artery atherosclerosis stroke) by using three single-nucleotide polymorphisms (SNPs) (rs198389, rs13107325, rs11105306) associated with NT-pro-BNP level (Johansson et al., 2016). The gene discussed is NPPB; the disease is cardioembolic stroke.