However, the genes that are relevant for mitochondrial FAO pathway (ACADS, ACADM, ACADL, HADHB, and ACOX) were expressed at significantly higher levels in RA monocytes than HCs (Figure 1F), suggesting the reduced content of lipids in RA monocytes induced by metabolic activation of the FAO pathway. The gene discussed is ACADL; the disease is rheumatoid arthritis.