In particular, the number of mature osteoclasts was significantly higher in RA patients with higher expression levels of CPT1A compared to patients with lower CPT1A expression (P <0.01), as was also found in case of osteoclast diameter (P <0.01), number of nuclei per osteoclast (P <0.01), and the pit area of bone resorption lacunae on day 21 (P <0.01) (Figure 2I–M). Here, CPT1A is linked to rheumatoid arthritis.