After correcting for multiple testing, IEIs caused by defects in the following 10 genes were associated with both eosinophilia and elevated IgE levels: ADA, CARD9, CYBB, DOCK8, FOXP3, IKBKG, NCF1, SPINK5, STAT3, WAS. The gene discussed is CARD9; the disease is Increased total eosinophil count.