Interestingly, several genes identified in our study including CTLA4, STAT3, IFNGR1, FOXP3, DOCK8, SPINK5, PIK3CD, TNFRSF13B, CXCR4, CARD11 and NLRP3 have been reported as candidate genes for allergic disease in genetic population studies (Figure 4) (38–46). The gene discussed is STAT3; the disease is allergic disease.