IL12RB1 and Increased total eosinophil count: Four genes categorized as defects in intrinsic and innate immunity were identified as being significantly associated with eosinophilia: IFNGR1, CARD9, CXCR4, and IL12RB1. Interferon-γ (IFN-γ) receptor 1 deficiency caused by loss-of-function variants in IFNGR1 predisposes to mycobacterial infections (54).