Eosinophilia and elevated serum IgE levels are two laboratory indicators of type 2 allergic inflammation, and are classically associated with PADs such as Wiskott-Aldrich syndrome (WAS), dedicator of cytokinesis 8 (DOCK8) deficiency, and immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome (15–19). This evidence concerns the gene DOCK8 and Increased total eosinophil count.