Another possibility in CGD is that deficient NADPH oxidase activity causes skewing towards type 2 inflammation; this possibility is supported a gp91phox-/- mouse model of allergic asthma, which showed increased peripheral and tissue eosinophils and production of Th2-specific cytokines compared to wild-type mice following allergen challenge (49). The gene discussed is CYBB; the disease is chronic granulomatous disease.