Moderate eosinophilia (above 1500 cells/ μL) was observed in PNP, LRBA, TNFRSF13B, CD40LG, IKBKG, NCF1, FOXP3, WAS, STAT3, CYBB, and DOCK8, with severe eosinophilia (above 5000 cells/ μL) observed in CXCR4, PIK3CD, CARD9 and DOCK8 (Figure 5 and Supplemental Table 1). The gene discussed is CXCR4; the disease is Increased total eosinophil count.