SPINK5 and Increased total eosinophil count: With correction for multiple testing, IEIs caused by defects in the following 29 genes were significantly associated with eosinophilia: STAT3, DOCK8, WAS, CYBB, NFKB2, NLRP3, ADA, IFNGR1, IKBKG, FOXP3, MAGT1, CARD9, SPINK5, RAG1, CTLA4, PIK3CD, TNFRSF13B, NCF1, PIK3R1, BTK, FAS, CD40LG, CXCR4, IL12RB1, PNP, LRBA, TBX1, CARD11, and RAG2 (Figure 3).