Conversely, many hormones with potential anti-inflammatory effects are reduced during T2D, such as CRH, DHEA, T4, testosterone, adiponectin, NGAL, GIP, GLP-1, and ghrelin, while ACTH, cortisol, glucagon, and C-peptide also have anti-inflammatory potential but are raised in T2D patient blood plasma. This evidence concerns the gene CRH and type 2 diabetes mellitus.