CD8A and liver cancer: Similarly, except for renal cell cancer (RCC) (32) and prostate cancer (33), CD8 T cell was regarded as a favorable prognostic marker and had been validated a variety of tumors, including ovarian cancer (34), liver cancer (35), breast cancer (36), and lung squamous cell carcinoma (37, 38), in the study of Romain Remark et al., the expression level of VEGF was positively associated with CD8 T immune cell infiltration in RCC, which might explain why high CD8 T cell infiltration leads to poor prognosis (32).