SPX was found to reduce the percentage of M1 macrophages and increase M2 ATMs, and to improve adipose tissue inflammation, metabolic profile and adipocyte hypertrophy during FRD induced obesity (43).Furthermore, these data reported in vivo could be, at least partly, because of the direct action of SPX on macrophage activation. The gene discussed is SPX; the disease is obesity due to melanocortin 4 receptor deficiency.