Furthermore, the results showed statistically significant differences in age, female proportion, BMI, SBP, DBP, hypertension, diabetes mellitus, NSTEMI, leukocyte count, hemoglobin, SCr, eGFR, FBG, TG, TC, low-density lipoprotein cholesterol (LDL-C) and HbA1c, three-vessel disease, multiple vessel disease, Gensini scores, oral hypoglycemic drugs, insulin, ACEI/ARB and beta-blockers among the four groups. This evidence concerns the gene INS and diabetes mellitus.