TARDBP and frontotemporal dementia: In 2018, a study on a cohort of FTD patients identified two different mutations, both characterized by the presence of diffuse TDP-43 immunoreactive neuronal intranuclear inclusions and dystrophic neurites and rare VCP inclusions (142), in contrast to a previous case report in which it was demonstrated the presence of VCP- and ubiquitin-positive cytoplasmic and nuclear aggregates in an Italian patients carrying the R159C mutation, and manifesting both body myopathy and FTD (143).