NPPB and stroke disorder: In a case-cohort analysis of the Reasons for Geographic and Racial Differences in Stroke cohort (n = 1,502, mean follow-up 5.4 years), patients in the highest quartile of serum NT-proBNP concentration had a 3-fold higher stroke risk than those in the lowest quartile (HR 2.9, 95% CI 1.9–4.5); the association was strongest for cardioembolic subtypes (HR 9.1, 95% CI 2.9–29.2), suggesting that the stroke risk was due to embolism (37).