Four indices were revealed to have a significant positive correlation with BPRS, including red blood cell count and blood urea nitrogen with hostile and suspiciousness subscale (r = 0.622, p = 0.013, and r = 0.598, p = 0.018, respectively), total bile acid with activation subscale (r = 0.579, p = 0.024), and IL-8 with anxiety-depression subscale (r = 0.704, p = 0.003). The gene discussed is CXCL8; the disease is major depressive disorder.